Clonality testing: teamwork by pathologist and molecular biologist
نویسندگان
چکیده
منابع مشابه
X-linked clonality testing: interpretation and limitations.
Clonality often defines the diseased state in hematology. Clonal cells are genetically homogenous and derived from the same precursor; their detection is based on genotype or phenotype. Genotypic clonality relies on somatic mutations to mark the clonal population. Phenotypic clonality identifies the clonal population by the expression pattern of surrogate genes that track the clonal process. Th...
متن کاملMolecular Testing in Microbiology
There are significant challenges associated with qualitative and quantitative nucleic acid tests performed in diagnostic laboratories. The development of internationally available certified reference materials which can be traced to reference measurements will contribute to a better understanding of the performance characteristics of nucleic acid tests and enhance reliability and comparability ...
متن کاملGenetics of asthma: a molecular biologist perspective
Asthma belongs to the category of classical allergic diseases which generally arise due to IgE mediated hypersensitivity to environmental triggers. Since its prevalence is very high in developed or urbanized societies it is also referred to as "disease of civilizations". Due to its increased prevalence among related individuals, it was understood quite long back that it is a genetic disorder. W...
متن کاملThe anatomic pathologist meets molecular pathology.
With the publication in this issue of " Stuck Between a Scalpel and a Rock, or Molecular Pathology and Legal-Ethical Issues in Use of Tissues for Clinical Care and Research: What Must a Pathologist Know? " by Dry et al, 1 we launch a new series for the American Journal of Clinical Pathology in a forward-looking celebration of the Journal's commitment to readers' education. It will include invit...
متن کاملMolecular analysis of clonality in Castleman's disease.
Castleman's disease (CD) is a rare atypical lymphoproliferative disorder that is morphologically and clinically heterogenous and is associated with a risk of developing malignant lymphoma. We report the clonality status of CD tissues in 34 patients, including 14 patients infected by the human immunodeficiency virus (HIV). Four patients presented a localized form and 30 presented a multicentric ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Hematopathology
سال: 2012
ISSN: 1868-9256,1865-5785
DOI: 10.1007/s12308-012-0143-y